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In 16 patients two weeks after the first uncomplicated myocardial infarction and in 10 control subjects we analyzed heart rate and systolic arterial pressure variabilities. During resting controlled conditions, patients presented an increased LF component of RR and systolic arterial pressure variabilities and a diminished HF component of RR variability. These changes were consistent with a sympathetic excitation and with a reduced vagal tone. The gain of baroreceptive mechanisms was assessed by analyzing the relationship between the spontaneous oscillations present in RR and systolic arterial pressure variabilities in the LF and HF frequency range and was found to be smaller in post-myocardial infarction patients than in control subjects. This non-invasive approach seems therefore capable of providing important information on the alteration on neural mechanisms controlling heart period and vasomotion after myocardial infarction.
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