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This study aimed to investigate barriers to the implementation and use of health information systems (HIS) in Iran by physician's view. This cross-sectional study was conducted in 2016 on 163 physicians employed in 10 teaching hospitals. Data collection was carried out through a questionnaire with questions about the technical, organizational, ethical and personal barrier categories. Data analysis demonstrated that technical (e.g. inadequate planning for implementation and use of HIS) (3.56±1.32), organizational (e.g. inadequate facilities for fast and easy access to the Internet) (3.67±1.91), personal (e.g. inadequate awareness of healthcare providers about the benefits of HIS) (3.33±1.28), as well as legal and ethical (e.g. concern about the security and confidentially of HIS) (3.15±1.31) were the most important barriers to the implementation and use of HIS. Reducing barriers, especially technical and personal ones will increase the implementation and use of HIS based on the physicians' perspectives.
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