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Introduction: Spine diseases such as scoliosis or spondylolisthesis affect the structure and composition of the intervertebral disc (IVD). These modifications can be assessed by MRI imaging.
Objectives: We hypothetise that the distribution of the MRI signal intensity within the IVD depends on the pathology and its severity.
Materials and methods: A 3D retrospective study was realized on 12 scoliotic cases of different severities (Cobb: 11°-50°) and 14 spondylolisthesis cases (Meyerding's grade I to V) using T2 weighted MRI (TR/TE = 3200/124). The IVD at the apex of the scoliotic curve or the L4-L5 disc for spondylolisthesis was selected. A pixel by pixel histogram of the normalised intensity (soft tissues /bone tissues) was achieved and analyzed using a two-way ANOVA. The considered factors were the pathology (Scoliosis/Spondylolisthesis) and its severity (Level I (Cobb≤20° or Spondylolisthesis grades I & II), level II (20°<Cobb≤40° or grade III) and level III (40°<Cobb or grades IV & V)).
Results: Significant differences were found in the signal intensity due to the severity of the pathology (p = 0,017-0,018) and to a linked interaction of pathology and severity (p = 0,021).
Conclusion: Inclusion of more patients will allow to conclude of the isolated effect of the pathology.
Significance: These results are suggesting that this new parameters describing the intensity distribution could be predictive factors of the potential progression of the disease. These factors should be investigated by contingency tables and validated by follow-up studies.
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