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Introduction: Our previous study revealed that Matrilin-1(MATN1) gene polymorphisms were association with occurrence and severity of adolescent idiopathic scoliosis (AIS).
Objective: To determine the circulating Matrilin-1 levels and its potential role in etiopathogenisis of AIS.
Materials and Methods: This study population consisted of 25 patients with AIS and 25 age-matched normal controls. The maximum Cobb angle and curve pattern of AIS group were recorded. AIS patients were categorized by progressive and non-progressive groups. Progression to a severe curve was defined per usual clinical criteria (progression to a >40° curve in an individual still growing or progression to a >50° curve in an adult). Genotyping and circulating Matrilin-1 were detected in both groups. The circulating Matrilin-1 levels were compared between AIS and control groups, and also among different genotype individuals. The relationship between Matrilin-1 levels and cure progression were also analyzed.
Results: A marked decrease of plasma Matrilin-1 levels was found in AIS groups (P=0.0002). We found Matrilin-1 levels in subjects with GG genotype tend to be lower than those with AA and AG genotypes in control groups, and this trend was stronger in AIS groups. Compared with non-progressive AIS group, plasma Matrilin-1 levels in progressive AIS group were significantly lower.
Conclusion and Significance: There is an association between Matrilin-1 levels and cure progression. Hence circulating Matrilin-1 level might be considered as an independent index to predict curve progression.
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